Cloned (Comment) | Organism |
---|---|
expressed as FLAG-tag fusion protein in COS-7 cells, construction of transgenic mice | Homo sapiens |
expression in COS7 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000045 | - |
F2-isoprostane-phosphocholine | purified recombinant plasma enzyme, 37°C | Homo sapiens | |
0.000057 | - |
F2-isoprostane-phosphocholine | purified recombinant PAF-acetylhydrolase, 37°C | Homo sapiens | |
0.0052 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | purified recombinant plasma enzyme, 37°C | Homo sapiens | |
0.0135 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | purified recombinant PAF-acetylhydrolase, 37°C | Homo sapiens | |
0.0193 | - |
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine | purified recombinant plasma enzyme, 37°C | Homo sapiens | |
0.0431 | - |
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine | purified recombinant PAF-acetylhydrolase, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
intracellular | - |
Homo sapiens | 5622 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | regulation of platelet-activating factor | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
F2-isoprostane phospholipid + H2O | Homo sapiens | plays key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo, involved in oxidative stress response | F2-isoprostane + phospholipid | - |
? | |
additional information | Homo sapiens | PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
Japanese patients with partial or complete plasma enzyme deficiency and control subjects | - |
Purification (Comment) | Organism |
---|---|
recombinant protein using FLAG-tag | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
blood plasma | enzyme associated with low-density lipoprotein and high-density lipoprotein | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
4.2 | - |
purifed enzyme using 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine as substrate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | regulation of platelet-activating factor | Homo sapiens | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 5-oxopentanoate + 1-palmitoyl-sn-glycero-3-phosphocholine | - |
? | |
F2-isoprostane phospholipid + H2O | plays key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo, involved in oxidative stress response | Homo sapiens | F2-isoprostane + phospholipid | - |
? | |
F2-isoprostane-phosphocholine + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAF-acetylhydrolase II | - |
Homo sapiens |
platelet-activating factor acetylhydrolase | - |
Homo sapiens |