Literature summary for 3.1.1.47 extracted from

Sumita, C.; Maeda, M.; Fujio, Y.; Kim, J.; Fujitsu, J.; Kasayama, S.; Yamamoto, I.; Azuma, J.
Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage (2004), Biochim. Biophys. Acta, 1673, 115-121.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	dose-dependent induction of enzyme expression by pioglitazone	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O	Homo sapiens	inactivation of platelet-activating factor, up-regulation of enzyme by pioglitazone reduces cell elongation	1-O-alkyl-sn-glycero-3-phosphocholine + acetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-
THP-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O	inactivation of platelet-activating factor, up-regulation of enzyme by pioglitazone reduces cell elongation	Homo sapiens	1-O-alkyl-sn-glycero-3-phosphocholine + acetate	-	?

Synonyms

Synonyms	Comment	Organism
PAF-AH	-	Homo sapiens
platelet-activating factor acetylhydrolase	-	Homo sapiens

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Release 2023.1 (January 2023)