Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharides | induce plasma enzyme expression in several tissues, overview, induction is 50% inhibited by administration of antagonists BN 50739 and WEB 2170 | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BN 50739 | antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression | Rattus norvegicus | |
WEB 2170 | antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Rattus norvegicus | i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
healthy and endotoxemic rats, plasma type enzyme | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | plasma isozyme | Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
Kupffer cell | only after induction of plasma isozyme expression by lipopolysaccharides | Rattus norvegicus | - |
leukocyte | circulating | Rattus norvegicus | - |
liver | lobule, Kupffer cells | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
macrophage | resident ones of the liver, and peritoneal | Rattus norvegicus | - |
plasma | - |
Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
thymus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAF acetylhydrolase | - |
Rattus norvegicus |
PAF-AH | - |
Rattus norvegicus |
platelet-activating factor acetylhadrolase | - |
Rattus norvegicus |