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Literature summary for 3.1.1.47 extracted from

  • Caslake, M.J.; Packard, C.J.
    Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease (2003), Curr. Opin. Lipidol., 14, 347-352.
    View publication on PubMed
Search for more literature for 3.1.1.47

Application

Application Comment Organism
diagnostics the enzyme is a positive risk factor for coronary disease and measurements of its amount may contribute to the prediction of coronary heart disease risk, especially in individuals with low LDL cholesterol levels Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene maps to chromosome 6q12.p21.1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
V279F naturally occurring mutantion, ecspecially in Japanese population, loss of enzyme activity, associated with increased risk of stroke and of coronary artery disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information secretory isozyme is Ca2+-independent Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
14000
-
 x * 14000, secretory isozyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens i.e. platelet-activation factor 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
additional information Homo sapiens the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylation is essential Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
artery wall
-
 Homo sapiens
-
macrophage increased enzyme expression in artheriosclerosis Homo sapiens
-
additional information wide tissue distribution Homo sapiens
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
additional information lipoprotein-associated enzyme does not hydrolyse native phospholipids Homo sapiens ?
-
 ?
additional information the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 14000, secretory isozyme Homo sapiens

Synonyms

Synonyms Comment Organism
lipoprotein-associated phospholipase A2
-
 Homo sapiens
Lp-PLA2
-
 Homo sapiens
PAF acetylhydrolase
-
 Homo sapiens
platelet-activating factor acetylhydrolase
-
 Homo sapiens