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Literature summary for 3.1.1.4 extracted from

  • Dileep, K.V.; Remya, C.; Cerezo, J.; Fassihi, A.; Perez-Sanchez, H.; Sadasivan, C.
    Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway (2015), Mol. Biosyst., 11, 1973-1979 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aspirin
-
Sus scrofa
gallic acid inhibitory in micromolar concentrations Sus scrofa
protocatechuic acid inhibitory in micromolar concentrations Sus scrofa
syringic acid inhibitory in micromolar concentrations Sus scrofa
vanillic acid inhibitory in micromolar concentrations Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P00592
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Sus scrofa
-

Synonyms

Synonyms Comment Organism
ppPLA2
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00095
-
gallic acid pH 8.5, 37°C Sus scrofa
0.00129
-
protocatechuic acid pH 8.5, 37°C Sus scrofa
0.00171
-
syringic acid pH 8.5, 37°C Sus scrofa
0.00232
-
vanillic acid pH 8.5, 37°C Sus scrofa
0.00827
-
aspirin pH 8.5, 37°C Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
pH 8.5, 37°C Sus scrofa gallic acid
0.00134
-
pH 8.5, 37°C Sus scrofa protocatechuic acid
0.00181
-
pH 8.5, 37°C Sus scrofa syringic acid
0.00245
-
pH 8.5, 37°C Sus scrofa vanillic acid
0.008742
-
pH 8.5, 37°C Sus scrofa aspirin

General Information

General Information Comment Organism
physiological function a key enzyme involved in the inflammatory pathway Sus scrofa