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Literature summary for 3.1.1.4 extracted from

  • Chuang, D.Y.; Simonyi, A.; Kotzbauer, P.T.; Gu, Z.; Sun, G.Y.
    Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway (2015), J. Neuroinflammation, 12, 199 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Mus musculus P0C871
-
-
Mus musculus P47713
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein on both primary and BV-2 microglial cells, stimulation with lipopolysaccharide or interferon gamma results in a time-dependent increase in phosphorylation of cPLA2 Mus musculus

Synonyms

Synonyms Comment Organism
Pla2g4a
-
 Mus musculus
Pla2g4b
-
 Mus musculus

General Information

General Information Comment Organism
malfunction primary microglial cells isolated from cPLA2alpha-deficient mice generate significantly less nitric oxide and reactive oxygen species as compared with the wild-type mice. Microglia isolated from iPLA2beta-deficient mice do not show a decrease in LPS-induced nitric oxide and reactive oxygen species production Mus musculus
physiological function the enzyme plays a crucial role in reactive oxygen species/nitric oxide signaling during microglial activation through the lipoxygenase pathway Mus musculus