Literature summary for 3.1.1.4 extracted from

Wang, H.; Klein, M.G.; Snell, G.; Lane, W.; Zou, H.; Levin, I.; Li, K.; Sang, B.C.
Structure of human GIVD cytosolic phospholipase A2 reveals insights into substrate recognition (2016), J. Mol. Biol., 428, 2769-2779 .

Search for more literature for 3.1.1.4

Application

Application	Comment	Organism
pharmacology	the enzyme is a potential drug target for developing a selective therapeutic agent for the treatment of psoriasis	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in insect cells (Sf9)	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
vapor diffusion at 4°C, X-ray structures of human cPLA2delta, capturing an apo state, and in complex with a substrate-like inhibitor	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
K554A/D555A/K556A	to crystallize apo-cPLA2d, three surface mutations (K554A, D555A, and K556A) are introduced to decrease surface entropy	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86XP0	-	-

Synonyms

Synonyms	Comment	Organism
GIVD cPLA2delta	-	Homo sapiens
PLA2G4D	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme generates lipid second messengers through hydrolysis of membrane-associated glycerophospholipids	Homo sapiens

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Release 2023.1 (January 2023)