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Literature summary for 3.1.1.4 extracted from

  • Jang, K.K.; Lee, Z.W.; Kim, B.; Jung, Y.H.; Han, H.J.; Kim, M.H.; Kim, B.S.; Choi, S.H.
    Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis (2017), J. Biol. Chem., 292, 17129-17143 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Protein Variants

Protein Variants Comment Organism
up plpA transcription is growth phase-dependent, reaching maximum levels during the early stationary phase. Transcription factor HlyU and cAMP receptor protein mediate additive activation and host-dependent induction of plpA Vibrio vulnificus

Organism

Organism UniProt Comment Textmining
Vibrio vulnificus
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Vibrio vulnificus MO6-24/O
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
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 Vibrio vulnificus 1-oleoyl-sn-glycero-3-phosphocholine + oleic acid
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 ?
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
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 Vibrio vulnificus MO6-24/O 1-oleoyl-sn-glycero-3-phosphocholine + oleic acid
-
 ?

Synonyms

Synonyms Comment Organism
plpA gtene name Vibrio vulnificus

General Information

General Information Comment Organism
malfunction compared with the wild type, the plpA mutant exhibis reduced mortality, systemic infection, and inflammation in mice as well as low cytotoxicity toward the human epithelial INT-407 cells Vibrio vulnificus
physiological function the enzyme is essential for pathogenesis Vibrio vulnificus