Literature summary for 3.1.1.4 extracted from

Naini, S.M.; Choukroun, G.J.; Ryan, J.R.; Hentschel, D.M.; Shah, J.V.; Bonventre, J.V.
Cytosolic phospholipase A2alpha regulates G1 progression through modulating FOXO1 activity (2016), FASEB J., 30, 1155-1170 .

Search for more literature for 3.1.1.4

Application

Application	Comment	Organism
pharmacology	pharmacological targeting of the enzyme may have important therapeutic benefits in disease mechanisms that involve excessive cell proliferation, in particular, cancer and proliferative glomerulopathies	Mus musculus
pharmacology	pharmacological targeting of the enzyme may have important therapeutic benefits in disease mechanisms that involve excessive cell proliferation, in particular, cancer and proliferative glomerulopathies	Danio rerio

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Mus musculus	5829	-
cytosol	-	Danio rerio	5829	-

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	P50392	-	-
Mus musculus	P47713	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	embryo, developing brain. The enzyme is moderately expressed in a cell cluster restricted to the forebrain and hindbrain with a clearer and more intense signal in the otic vesicles	Danio rerio	-
fibroblast	embryonic	Mus musculus	-
mesangial cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
cPLA2alpha	-	Mus musculus
cPLA2alpha	-	Danio rerio
phospholipase A2alpha	-	Mus musculus
phospholipase A2alpha	-	Danio rerio

Expression

Organism	Comment	Expression
Danio rerio	the transcript is readily detectable at 12 h postfertilization and continues to be expressed at similar level until 72 h, after which the expression declines dramatically. Protein expression is detectable at 12 h, with peak expression occurring between 24 and 34 h postfertilization	up

General Information

General Information	Comment	Organism
malfunction	lack of cPLA2alpha prolongs the G1 phase and reduces the proliferating capacity in response to mitogen stimulation without a significant change in the duration of the other phases of the cell cycle	Mus musculus
malfunction	loss of cpla2a expression or inhibition of cpla2a activity diminishes G1 progression through the cell cycle	Danio rerio
metabolism	through its phospholipase activity, the enzyme is a critical effector ofG1 phase progression through the cell cycle	Danio rerio
physiological function	cpla2a genes play an important role in the development of the brain region	Danio rerio
physiological function	the enzyme is a key mediator of inflammation and tumorigenesis	Danio rerio
physiological function	the enzyme plays an important role in induction of cell cycle progression at the G1 phase in mesangial cells through inhibition of FOXO1 activity	Mus musculus

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Release 2023.1 (January 2023)