Literature summary for 3.1.1.4 extracted from

Aragao, E.A.; Vieira, D.S.; Chioato, L.; Ferreira, T.L.; Lourenzoni, M.R.; Silva, S.R.; Ward, R.J.
Characterization of suramin binding sites on the human group IIA secreted phospholipase A2 by site-directed mutagenesis and molecular dynamics simulation (2012), Arch. Biochem. Biophys., 519, 17-22.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D49K	suramin affinity is increased, inhibitory effect of suramin in relation to wild-type protein is enhanced	Homo sapiens
DELTAK57/R58	suramin affinity is significantly increased	Homo sapiens
H48Q	inhibitory effect of suramin in relation to wild-type protein is enhanced	Homo sapiens
K116A	suramin affinity is increased, inhibitory effect of suramin in relation to wild-type protein is enhanced	Homo sapiens
K123A	suramin affinity is significantly reduced, inhibitory effect of suramin in relation to wild-type protein is reduced	Homo sapiens
K15A	suramin affinity is significantly reduced, inhibitory effect of suramin in relation to wild-type protein is reduced	Homo sapiens
additional information	The changes in suramin binding affinity of cationic residue mutants of is strongly correlated with alterations in the inhibition of membrane damaging activity of the protein	Homo sapiens
R54A	suramin affinity is significantly reduced, inhibitory effect of suramin in relation to wild-type protein is reduced	Homo sapiens
R58A	inhibitory effect of suramin in relation to wild-type protein is reduced	Homo sapiens
R7A	inhibitory effect of suramin in relation to wild-type protein is reduced	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
suramin	the C-terminal region of the enzyme is crucial to the stabilization of the complex with suramin and consequently is a major structural determinant of the inhibitory action of suramin	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14555	-	-

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Release 2023.1 (January 2023)