Literature summary for 3.1.1.4 extracted from

Escoffier, J.; Pierre, V.; Jemel, I.; Munch, L.; Boudhraa, Z.; Ray, P.; De Waard, M.; Lambeau, G.; Arnoult, C.
Group X secreted phospholipase A2 specifically decreases sperm motility in mice (2011), J. Cell. Physiol., 226, 2601-2609.

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Protein Variants

Protein Variants	Comment	Organism
H48Q	mutant with very weak enzymatic activity	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
LY 329722	specific inhibitor of secreted phospholipase A2	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sperm	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
group X secreted phospholipase A2	-	Mus musculus
GX sPLA2	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	group X secreted phospholipase A2 (sPLA2) acts as a potent inhibitor of sperm motility that decreases track speed and lateral displacement of the head of both noncapacitated and capacitated sperm. sPLA2 selects a sperm subpopulation for fertilization based on its effect on sperm motility	Mus musculus

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Release 2023.1 (January 2023)