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Literature summary for 3.1.1.4 extracted from

  • Dreiseitel, A.; Korte, G.; Schreier, P.; Oehme, A.; Locher, S.; Hajak, G.; Sand, P.G.
    sPhospholipase A(2) is inhibited by anthocyanidins (2009), J. Neural Transm., 116, 1071-1077.
    View publication on PubMed
Search for more literature for 3.1.1.4

Application

Application Comment Organism
drug development partial inhibition of PLA2-V by most fruit antioxidants may prove advantageous in vivo in that basal levels of phospholipid-derived mediators may be maintained for normal brain function. The sPLA2-V inhibition by anthocyanidins provides further evidence to rationalize antioxidative and antiinflammatory activities Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
catechin reaches 50% inhibition at concentrations of 2.5 mM Homo sapiens
cyanidin mixed competitive and noncompetitive inhibition, partial hyperbolic type of inhibition Homo sapiens
delphinidin mixed competitive and noncompetitive inhibition, complete inhibition Homo sapiens
malvidin partial competitive inhibition Homo sapiens
additional information anthocyanidins exhibit the best inhibitory effects on PLA2, whereas inhibitory properties of anthocyanins are less pronounced Homo sapiens
pelargonidin mixed competitive and noncompetitive inhibition, complete inhibition Homo sapiens
peonidin mixed competitive and noncompetitive inhibition, partial hyperbolic type of inhibition Homo sapiens
petunidin mixed competitive and noncompetitive inhibition, partial hyperbolic type of inhibition Homo sapiens
protocatechuic acid reaches 50% inhibition at concentrations of 3.3 mM Homo sapiens
thioetheramide phosphatidylcholine exhibits complete competitive inhibition Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for catalysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-bis(heptanoylthio)-glycerophosphocholine + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PLA2-V
-
 Homo sapiens
secretory phospholipase A2
-
 Homo sapiens
sPLA2
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00059
-
 thioetheramide phosphatidylcholine in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
0.0021
-
 cyanidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
0.0064
-
 malvidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
0.01
-
 peonidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
0.014
-
 petunidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
0.018
-
 delphinidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
0.325
-
 pelargonidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens