Application | Comment | Organism |
---|---|---|
drug development | herbal compounds (acalyphin, chlorogenic acid, stigmasterol, curcumin and tectoridin) and marine compounds (gracilin A and aplysulphurin A) show favorable interactions with the amino acid residues at the active site of PLA2, thereby substantiating their proven efficacy as anti-inflammatory compounds and antidotes | Bos taurus |
drug development | herbal compounds (acalyphin, chlorogenic acid, stigmasterol, curcumin and tectoridin) and marine compounds (gracilin A and aplysulphurin A) show favorable interactions with the amino acid residues at the active site of PLA2, thereby substantiating their proven efficacy as anti-inflammatory compounds and antidotes | Daboia russelii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acalyphin | from Acalypha indica, shows interaction with the amino acids at the active site of PLA2, interacts also with the Ca2+ ion in the active site of PLA2 | Bos taurus | |
acalyphin | from Acalypha indica, shows interaction with the amino acids (Asp-49, Lys-69 and Gly-30) at the active site of PLA2 | Daboia russelii | |
aplysulphurin A | from Aplysilla sp., shows interaction with the amino acids at the active site of PLA2, interacts also with the Ca2+ ion in the active site of PLA2 | Bos taurus | |
aplysulphurin A | from Aplysilla sp., shows interaction with the amino acids at the active site of PLA2 | Daboia russelii | |
chlorogenic acid | from Achillea millefolium, shows interaction with the amino acids at the active site of PLA2 | Bos taurus | |
chlorogenic acid | from Achillea millefolium, shows interaction with the amino acids (Asp-49, Lys-69, Trp-31 and Trp-A31) at the active site of PLA2 | Daboia russelii | |
curcumin | from Curcuma longa, shows interaction with the amino acids at the active site of PLA2 | Bos taurus | |
curcumin | from Curcuma longa, shows interaction with the amino acids (Asp-49 and Gly-30) at the active site of PLA2 | Daboia russelii | |
gracilin A | from Aplysilla sp., shows interaction with the amino acids at the active site of PLA2, interacts also with the Ca2+ ion in the active site of PLA2 | Bos taurus | |
gracilin A | from Aplysilla sp., shows interaction with the amino acids (Asp-49, His-48, Trp-31 and Gly-30) at the active site of PLA2 | Daboia russelii | |
stigmasterol | from Achillea millefolium, shows interaction with the amino acids at the active site of PLA2 | Bos taurus | |
stigmasterol | from Achillea millefolium, shows interaction with the amino acids (His-48) at the active site of PLA2 | Daboia russelii | |
tectoridin | from Belamcanda chinensis, shows interaction with the amino acids at the active site of PLA2 | Bos taurus | |
tectoridin | from Belamcanda chinensis, shows interaction with the amino acids (Asp-49 and Lys-69) at the active site of PLA2 | Daboia russelii |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | essential for catalysis and substrate binding | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P00593 | - |
- |
Daboia russelii | P59071 | Russell's viper | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Bos taurus | - |
Synonyms | Comment | Organism |
---|---|---|
phospholipase A2 | - |
Bos taurus |
phospholipase A2 | - |
Daboia russelii |
PLA2 | - |
Bos taurus |
PLA2 | - |
Daboia russelii |