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Literature summary for 3.1.1.4 extracted from

  • Chalbot, S.; Zetterberg, H.; Blennow, K.; Fladby, T.; Grundke-Iqbal, I.; Iqbal, K.
    Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease (2009), Clin. Chem., 55, 2171-2179.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Application

Application Comment Organism
medicine potential of PLA2 as a biomarker in screening neuroinflammatory disorders in both clinical and research settings Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine competitive inhibitor toward sPLA2, dose-dependent inhibition Homo sapiens
1-palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine competitive inhibitor toward recombinant sPLA2, dose-dependent inhibition Mus musculus
additional information is not inhibited by bromoenol lactone or AACOCF3 (arachidonyl trifluoromethyl ketone) Homo sapiens
additional information recombinant sPLA2 is not inhibited by bromoenol lactone or AACOCF3 (arachidonyl trifluoromethyl ketone) Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ is required for catalytic activity. With increase in the concentration of calcium, increase of recombinant PLA2 activity Homo sapiens
Ca2+ is required for catalytic activity. With increase in the concentration of calcium, increase of recombinant sPLA2 activity Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebrospinal fluid
-
 Homo sapiens
-
serum sPLA2 activity relative to protein concentration is 2.5fold higher in serum than in lumbar cerebrospinal fluid Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
-
 Mus musculus ?
-
 ?
1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens ?
-
 ?
1,2-dioleoyl-L-alpha-phosphatidylcholine + H2O
-
 Mus musculus ?
-
 ?
1,2-dioleoyl-L-alpha-phosphatidylcholine + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
secretory Ca2+-dependent PLA2
-
 Mus musculus
secretory Ca2+-dependent PLA2
-
 Homo sapiens
sPLA2
-
 Mus musculus
sPLA2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function sPLA2 activity is present in lumbar cerebrospinal fluid from healthy individuals 20-77 years old that does not depend on either sex or age. Cerebrospinal fluid sPLA2 activity is increased in patients with Alzheimer disease Homo sapiens