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Literature summary for 3.1.1.4 extracted from

  • Wang, W.Y.; Li, J.; Yang, D.; Xu, W.; Zha, R.P.; Wang, Y.P.
    OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways (2010), Cardiovasc. Res., 85, 845-852.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
SB435495 SB435495-treated oxidized low density lipoprotein has nearly undetectable lp-PLA2 activity. Completely inhibits lp-PLA2 enzyme activity in the whole culture media of THP-1 cells with 0.0001 mM Homo sapiens
SB480848 darapladib, completely inhibits lp-PLA2 enzyme activity in the whole culture media of THP-1 cells with 0.0001 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-sn-glycerol-3-phosphocholine + H2O
-
Homo sapiens ?
-
?
oxidized high density lipoprotein + H2O
-
Homo sapiens ?
-
?
oxidized low density lipoprotein + H2O
-
Homo sapiens ?
-
?
platelet activating factor + H2O
-
Homo sapiens lyso-platelet activating factor
-
?

Synonyms

Synonyms Comment Organism
lipoprotein-associated phospholipase A2
-
Homo sapiens
Lp-PLA2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens unstimulated and low density lipoprotein-treated THP-1 cells fail to produce detectable levels of lp-PLA2. Inhibition of either phosphatidylinositol 3-kinase (by LY294002 and wortmannin) or p38 mitogen-activating protein kinase (by SB203580 and SB202190) completely blocks oxidized low density lipoprotein-induced lp-PLA2 expression. Neither platelet activating factor and lyso-platelet activating factor nor 1-palmitoyl-sn-glycerol-3-phosphocholine and high density lipoprotein can induce lp-PLA2 expression down
Homo sapiens oxidized low density lipoprotein, and more specifically its unhydrolyzed oxidized phospholipids, upregulate lp-PLA2 expression in monocytes through the phosphatidylinositol 3-kinase and p38 mitogen-activating protein kinase pathway. Oxidized low density lipoprotein-treated cells produce lp-PLA2 mRNA in a concentration- and time-dependent manner. Oxidized high density lipoprotein can also induce lp-PLA2 expression up

General Information

General Information Comment Organism
malfunction inhibition of lp-PLA2 activity in conditioned medium by SB435495 or SB480848 significantly decreases lipid accumulation in macrophages Homo sapiens
physiological function lp-PLA2 promotes lipoprotein uptake in macrophages Homo sapiens