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Literature summary for 3.1.1.4 extracted from

  • Baskakis, C.; Magrioti, V.; Cotton, N.; Stephens, D.; Constantinou-Kokotou, V.; Dennis, E.A.; Kokotos, G.
    Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes (2008), J. Med. Chem., 51, 8027-8037.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
(4S)-4-[(2-oxohexadecanoyl)amino]nonanoic acid
-
 Homo sapiens
(5S)-5-[(2-oxohexadecanoyl)amino]decanoic acid
-
 Homo sapiens
(6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
-
 Homo sapiens
1,1,1,2,2-pentafluoro-5-(4-hexyloxy-phenyl)-pentan-3-one
-
 Homo sapiens
1,1,1,2,2-pentafluoro-7-phenyl-heptan-3-one a selective inhibitor of GVIA iPLA2 Homo sapiens
1,1,1,2,2-pentafluoro-8-phenyl-octan-3-one
-
 Homo sapiens
1,1,1,2,2-pentafluoro-9-phenyl-nonan-3-one
-
 Homo sapiens
1,1,1,2,2-pentafluoro-octadecan-3-one
-
 Homo sapiens
1,1,1,3,3-pentafluoro-6-phenyl-hexane-2,2-diol
-
 Homo sapiens
1,1,1,3-tetrafluoro-heptadecan-2-one
-
 Homo sapiens
1,1,1-trifluoro-4-(4-hexyloxy-phenyl)-butan-2-one
-
 Homo sapiens
1,1,1-trifluoro-6-(4-hexyloxy-phenyl)-hexan-2-one
-
 Homo sapiens
1,1,1-trifluoro-6-phenylhexan-2-one
-
 Homo sapiens
1,1,1-trifluoro-7-phenylheptan-2-one
-
 Homo sapiens
1,1,1-trifluoro-8-phenyloctan-2-one
-
 Homo sapiens
1,1,1-trifluoroheptadecan-2-one
-
 Homo sapiens
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-3-(methoxycarbonyl)-1H-indole-5-carboxylic acid
-
 Homo sapiens
4-(4-benzyloxy-phenyl)-1,1,1-trifluoro-butan-2-one
-
 Homo sapiens
4-(4-decyloxy-phenyl)-1,1,1-trifluoro-butan-2-one
-
 Homo sapiens
4-[(2-oxohexadecanoyl)amino]butanoic acid
-
 Homo sapiens
4-[2-[5-chloro-2-(2-[[(3,4-dichlorobenzyl)sulfonyl]amino]ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy]benzoic acid
-
 Homo sapiens
4-[3-[5-chloro-2-(2-[[(3,4-dichlorobenzyl)sulfonyl]amino]ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl]benzoic acid
-
 Homo sapiens
4-[4-[2-([2-[bis(4-chlorophenyl)methoxy]ethyl]sulfonyl)ethoxy]phenyl]-1,1,1-trifluorobutan-2-one
-
 Homo sapiens
6-(4-decyloxy-phenyl)-1,1,1-trifluoro-hexan-2-one
-
 Homo sapiens
ethyl 4-[(2-oxohexadecanoyl)amino]butanoate
-
 Homo sapiens
additional information synthesis of fluoroketone inhibitors and inhibitory effects against isozymes group IVA cytosolic phospholipase A2, , group V secreted phospholipase A2, and group VIA calcium-independent phospholipase A2, overview. Trifluoromethyl ketone analogues of arachidonic and palmitic acids also inhibit GVIA iPLA2 Homo sapiens
N-[[(2S,4R)-1-([2-[(2,4-difluorophenyl)carbonyl]phenyl]carbonyl)-4-(tritylsulfanyl)pyrrolidin-2-yl]methyl]-4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the enzyme is Ca2+-independent Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
GIVA cPLA2
-
 Homo sapiens
group IVA cPLA2
-
 Homo sapiens
group IVA cytosolic phospholipase A2
-
 Homo sapiens
group V secreted phospholipase A2
-
 Homo sapiens
group VIA calcium-independent phospholipase A
-
 Homo sapiens
GV sPLA2
-
 Homo sapiens
GVIA iPLA2
-
 Homo sapiens
phospholipase A2
-
 Homo sapiens