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Literature summary for 3.1.1.4 extracted from

  • Monti, M.C.; Casapullo, A.; Cavasotto, C.N.; Tosco, A.; Dal Piaz, F.; Ziemys, A.; Margarucci, L.; Riccio, R.
    The binding mode of petrosaspongiolide M to the human group IIA phospholipase A2: exploring the role of covalent and noncovalent interactions in the inhibition process (2009), Chemistry, 15, 1155-1163.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
25-O-acetyl-petrosaspongiolide M an anti-inflammatory marine natural product Homo sapiens
additional information structural analysis of PLA2-inhibitor complexes, computational and mass spectrometry analysis, molecular dynamics simulations, overview Homo sapiens
petrosaspongiolide M an anti-inflammatory marine natural product, mechanism of sPLA2-IIA inactivation, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the secretory isozyme is Ca2+-dependent Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14555
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sPLA2-IIA activity assays using the fluorescent probe ADIFAB, which consists of an acrylodan derivative of rat intestinal fatty acid binding protein that exhibits a shift in fluorescence upon binding to long-chain native fatty acids Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Group IIA phospholipase A2
-
Homo sapiens
group IIA secretory phospholipase A2
-
Homo sapiens
sPLA2-IIA
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens