Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.4 extracted from

  • Song, H.; Ramanadham, S.; Bao, S.; Hsu, F.F.; Turk, J.
    A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols (2006), Biochemistry, 45, 1061-1073.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C651A catalytic activity similar to wild-type, inactivation by (6E)-6-(bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one requires higher concentrations than for wild-type Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(6E)-6-(bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one i.e. BEL, bromoenol lactone suicide inhibitor, alkylates Cys-residues Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-