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Literature summary for 3.1.1.4 extracted from

  • Akiba, S.; Dodia, C.; Chen, X.; Fisher, A.B.
    Characterization of acidic Ca2+-independent phospholipase A2 of bovine lung (1998), Comp. Biochem. Physiol. B, 120, 393-404.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol MJ33, competitive inhibitor Bos taurus
3,4-dichloroisocoumarin
-
Bos taurus
3,4-dichloroisocoumarin
-
Homo sapiens
anti-peptide antibody
-
Bos taurus
Diethyl p-nitrophenyl phosphate
-
Bos taurus
Diethyl p-nitrophenyl phosphate
-
Homo sapiens
diisopropyl fluorophosphate
-
Bos taurus
diisopropyl fluorophosphate
-
Homo sapiens
phenylmethylsulfonyl fluoride
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
cytoplasm
-
Bos taurus 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Homo sapiens
Ca2+
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
-
Homo sapiens
29000
-
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phospholipids + H2O Homo sapiens
-
?
-
?
phospholipids + H2O Bos taurus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
cow
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification, 176fold Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
lung
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.027
-
acidic iPLA2, substrate: 1-O-hexadecyl-2-arachidonoyl-glycero-3-phosphocholine Bos taurus
0.064
-
acidic iPLA2, substrate: 1-palmitoyl-2-arachidonylphosphatidylcholine or 1,2-dipalmitoyl-phosphatidylcholine Bos taurus
0.065
-
acidic iPLA2, substrate: oxidized 1-palmitoyl-2-arachidonylphosphatidylcholine Bos taurus
0.08
-
acidic iPLA2, pH 4.0, Ca2+-free medium, substrate: 1,2-dipalmitoyl-phosphatidylcholine Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dipalmitoyl-phosphatidylcholine + H2O
-
Homo sapiens 1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
-
Bos taurus 1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
?
1-O-hexadecyl-2-arachidonyl-glycero-3-phosphocholine + H2O
-
Bos taurus 1-O-hexadecyl-glycero-3-phosphocholine + arachidonic acid
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
-
Homo sapiens 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
-
Bos taurus 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
?
oxidized phosphatidylcholines + H2O
-
Homo sapiens 1-acylglycerophosphocholine + oxidized fatty acids
-
?
oxidized phosphatidylcholines + H2O oxidized 1-palmitoyl-2-arachidonoylphosphatidylcholine for substrate Bos taurus 1-acylglycerophosphocholine + oxidized fatty acids
-
?
phosphatidylcholine + H2O
-
Homo sapiens 1-acylglycerophosphocholine + fatty acid
-
?
phosphatidylcholine + H2O
-
Bos taurus 1-acylglycerophosphocholine + fatty acid
-
?
phospholipids + H2O
-
Homo sapiens ?
-
?
phospholipids + H2O
-
Bos taurus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4
-
at pH 7.4 or 8.5 the activity of acidic iPLA2 decreased above 97% Bos taurus