Cloned (Comment) | Organism |
---|---|
into pET28a(+) vector, transformation of Escherichia coli strain BL21 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(3-acetamido-2-benzyl-2-ethylindolyl-5-oxy)propane phosphonic acid | LY311727, IC50 value of 36 nM, group IIa and V sPLA2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
secretory granule | - |
Homo sapiens | 30141 | - |
secretory granule | - |
Rattus norvegicus | 30141 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
Ca2+ | - |
Homo sapiens | |
Ca2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
16000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipids + H2O | Homo sapiens | influence on platelet aggregation | ? | - |
? | |
phospholipids + H2O | Rattus norvegicus | influence on platelet aggregation | ? | - |
? | |
phospholipids + H2O | Homo sapiens | signal transduction | ? | - |
? | |
phospholipids + H2O | Mus musculus | eicosanoids | ? | - |
? | |
phospholipids + H2O | Homo sapiens | eicosanoids | ? | - |
? | |
phospholipids + H2O | Rattus norvegicus | eicosanoids | ? | - |
? | |
phospholipids + H2O | Homo sapiens | inflammatory diseases | ? | - |
? | |
phospholipids + H2O | Rattus norvegicus | inflammatory diseases | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA affinity chromatography | Homo sapiens |
Renatured (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
leukocyte | peripheral blood | Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
placenta | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.5 | - |
substrate: 1-palmitoyl-2-arachidonylphosphatidylcholine | Homo sapiens |
1.8 | - |
substrate: 1-palmitoyl-2-linoleoylphosphatidylcholine | Homo sapiens |
3.22 | - |
substrate: 1,2-dipalmitoyl-phosphatidylcholine | Homo sapiens |
Storage Stability | Organism |
---|---|
-4°C, for months without losing enzymatic activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Rattus norvegicus | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O | - |
Rattus norvegicus | 1-palmitoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O | - |
Rattus norvegicus | 1-palmitoyl-glycerophosphorylcholine + linolic acid | - |
? | |
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O | group V sPLA2 | Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + linolic acid | - |
? | |
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylethanolamine + linolic acid | - |
? | |
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O | - |
Rattus norvegicus | 1-palmitoyl-glycerophosphorylethanolamine + linolic acid | - |
? | |
phospholipids + H2O | influence on platelet aggregation | Homo sapiens | ? | - |
? | |
phospholipids + H2O | influence on platelet aggregation | Rattus norvegicus | ? | - |
? | |
phospholipids + H2O | signal transduction | Homo sapiens | ? | - |
? | |
phospholipids + H2O | eicosanoids | Mus musculus | ? | - |
? | |
phospholipids + H2O | eicosanoids | Homo sapiens | ? | - |
? | |
phospholipids + H2O | eicosanoids | Rattus norvegicus | ? | - |
? | |
phospholipids + H2O | inflammatory diseases | Homo sapiens | ? | - |
? | |
phospholipids + H2O | inflammatory diseases | Rattus norvegicus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000036 | - |
LY311727, IC50 value of 36 nM, group IIa and V sPLA2 | Homo sapiens | 3-(3-acetamido-2-benzyl-2-ethylindolyl-5-oxy)propane phosphonic acid |