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Literature summary for 3.1.1.4 extracted from

  • Chen, D.; Dennis, E.A.
    Expression and characterization of human group V phospholipase A2 (1998), Biochim. Biophys. Acta, 1394, 57-64.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
into pET28a(+) vector, transformation of Escherichia coli strain BL21 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-(3-acetamido-2-benzyl-2-ethylindolyl-5-oxy)propane phosphonic acid LY311727, IC50 value of 36 nM, group IIa and V sPLA2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule
-
Homo sapiens 30141
-
secretory granule
-
Rattus norvegicus 30141
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Mus musculus
Ca2+
-
Homo sapiens
Ca2+
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
16000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phospholipids + H2O Homo sapiens influence on platelet aggregation ?
-
?
phospholipids + H2O Rattus norvegicus influence on platelet aggregation ?
-
?
phospholipids + H2O Homo sapiens signal transduction ?
-
?
phospholipids + H2O Mus musculus eicosanoids ?
-
?
phospholipids + H2O Homo sapiens eicosanoids ?
-
?
phospholipids + H2O Rattus norvegicus eicosanoids ?
-
?
phospholipids + H2O Homo sapiens inflammatory diseases ?
-
?
phospholipids + H2O Rattus norvegicus inflammatory diseases ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA affinity chromatography Homo sapiens

Renatured (Commentary)

Renatured (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-
leukocyte peripheral blood Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.5
-
substrate: 1-palmitoyl-2-arachidonylphosphatidylcholine Homo sapiens
1.8
-
substrate: 1-palmitoyl-2-linoleoylphosphatidylcholine Homo sapiens
3.22
-
substrate: 1,2-dipalmitoyl-phosphatidylcholine Homo sapiens

Storage Stability

Storage Stability Organism
-4°C, for months without losing enzymatic activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dipalmitoyl-phosphatidylcholine + H2O
-
Homo sapiens 1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
-
Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
-
Homo sapiens 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
-
Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
-
Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + linolic acid
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O group V sPLA2 Homo sapiens 1-palmitoyl-glycerophosphorylcholine + linolic acid
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
-
Homo sapiens 1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
-
Rattus norvegicus 1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
?
phospholipids + H2O influence on platelet aggregation Homo sapiens ?
-
?
phospholipids + H2O influence on platelet aggregation Rattus norvegicus ?
-
?
phospholipids + H2O signal transduction Homo sapiens ?
-
?
phospholipids + H2O eicosanoids Mus musculus ?
-
?
phospholipids + H2O eicosanoids Homo sapiens ?
-
?
phospholipids + H2O eicosanoids Rattus norvegicus ?
-
?
phospholipids + H2O inflammatory diseases Homo sapiens ?
-
?
phospholipids + H2O inflammatory diseases Rattus norvegicus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000036
-
LY311727, IC50 value of 36 nM, group IIa and V sPLA2 Homo sapiens 3-(3-acetamido-2-benzyl-2-ethylindolyl-5-oxy)propane phosphonic acid