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Literature summary for 3.1.1.34 extracted from
- Purification and characterization of lipoprotein lipase from human postheparin plasma and its comparison with purified bovine milk lipoprotein lipase (1986), J. Biochem., 100, 319-331.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apolipoprotein C-II | cofactor | Homo sapiens | |
| apolipoprotein C-II | cofactor | Bos taurus | |
| apolipoprotein C-II | Km: 0.001 mM | Homo sapiens | |
| apolipoprotein C-II | Km: 0.00015 mM | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | 1 M NaCl, 90% inhibition | Bos taurus |  |
| NaCl | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.5 | - |
triolein | - |
Bos taurus | |
| 2.5 | - |
triolein | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
x * 56000, SDS-PAGE | Bos taurus |
| 58000 | - |
x * 58000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | plays a key role in the metabolism of the triglyceride-rich lipoproteins, namely chylomicrons and very-low-density lipoproteins | ? | - |
? | |
| additional information | Bos taurus | plays a key role in the metabolism of the triglyceride-rich lipoproteins, namely chylomicrons and very-low-density lipoproteins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| milk | - |
Homo sapiens | - |
| milk | - |
Bos taurus | - |
| plasma | postheparin | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 431.6 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C, 1% serum albumin, 1 h, 60% loss of activity | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | plays a key role in the metabolism of the triglyceride-rich lipoproteins, namely chylomicrons and very-low-density lipoproteins | Homo sapiens | ? | - |
? | |
| additional information | plays a key role in the metabolism of the triglyceride-rich lipoproteins, namely chylomicrons and very-low-density lipoproteins | Bos taurus | ? | - |
? | |
| triolein + H2O | - |
Homo sapiens | ? | - |
? | |
| triolein + H2O | - |
Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 56000, SDS-PAGE | Bos taurus |
| ? | x * 58000, SDS-PAGE | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
10 min, absence of apop C-II, 15% loss of activity | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.7 | - |
- |
Homo sapiens |
| 8.7 | - |
- |
Bos taurus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 8.9 | pH 7.2: about 45% of maximal activity, pH 8.9: about 95% of maximal activity | Bos taurus |
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