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Literature summary for 3.1.1.34 extracted from

  • Wang, Z.; Li, S.; Sun, L.; Fan, J.; Liu, Z.
    Comparative analyses of lipoprotein lipase, hepatic lipase, and endothelial lipase, and their binding properties with known inhibitors (2013), PLoS ONE, 8, e72146.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
3-[4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-3-yl]propanoic acid
-
 Homo sapiens
4-ethylphenylboronic acid
-
 Homo sapiens
4-nonylphenylboronic acid
-
 Homo sapiens
4-tert-butyl-N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)phenyl]benzamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P06858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Homo sapiens
-
muscle
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
LPL
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 pH and temperature not specified in the publication Homo sapiens 4-tert-butyl-N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)phenyl]benzamide
0.0014
-
 pH and temperature not specified in the publication Homo sapiens 4-nonylphenylboronic acid
0.02
-
 pH and temperature not specified in the publication Homo sapiens 4-ethylphenylboronic acid
0.5
-
 pH and temperature not specified in the publication Homo sapiens 3-[4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-3-yl]propanoic acid

General Information

General Information Comment Organism
physiological function the up-regulation of enzyme activity may be beneficial in obesity and diabetes Homo sapiens