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Literature summary for 3.1.1.34 extracted from

  • Kersten, S.
    Physiological regulation of lipoprotein lipase (2014), Biochim. Biophys. Acta, 1841, 919-933.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
angiopoietin-like protein 4 major physiological regulator of enzyme activity under conditions of fasting and exercise Mus musculus
apolipoprotein A5
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ANGPTL4 conventional, non-competitive inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Mus musculus
-
diacylglycerol + a carboxylate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brown adipose tissue
-
Mus musculus
-
heart
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
lung
-
Mus musculus
-
macrophage
-
Mus musculus
-
mammary gland
-
Mus musculus
-
skeletal muscle
-
Mus musculus
-
white adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
triacylglycerol + H2O
-
Mus musculus diacylglycerol + a carboxylate
-
?

Subunits

Subunits Comment Organism
dimer
-
Mus musculus

Synonyms

Synonyms Comment Organism
LPL
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus stress and catecholamines reduce adipose enzyme activity. Tissue necrosis factpor alpha represses enzyme activity by downregulating transcription down
Mus musculus insulin, dexamethasone and cortisol increase mRNA and activity in adipose organs. Cold markedly stimulates enzyme activity in brown adipose tissue up

General Information

General Information Comment Organism
physiological function the enzyme is rate limiting for plasma triglyceride clearance and tissue uptake of fatty acids Mus musculus