Literature summary for 3.1.1.34 extracted from

Pappan, K.L.; Pan, Z.; Kwon, G.; Marshall, C.A.; Coleman, T.; Goldberg, I.J.; McDaniel, M.L.; Semenkovich, C.F.
Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion (2005), J. Biol. Chem., 280, 9023-9029.

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Protein Variants

Protein Variants	Comment	Organism
additional information	transgenic animals with beta-cell-specific overexpression or inactivation of enzyme. Enzyme activity and triglyceride content is increased in overexpressing islets, decreased enzyme activity enzyme-inactivated islets does not affect islets triglyceride content. Both overexpressing and enzyme-inactivited mice are strikingly hyperglycemic during glucose tolerance testing, and both show impaired glucose-simulated insulin secretion	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	transgenic animals with beta-cell-specific overexpression or inactivation of enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	transgenic animals with beta-cell-specific overexpression or inactivation of enzyme. Enzyme activity and triglyceride content is increased in overexpressing islets, decreased enzyme activity enzyme-inactivated islets does not affect islets triglyceride content. Both overexpressing and enzyme-inactivited mice are strikingly hyperglycemic during glucose tolerance testing, and both show impaired glucose-simulated insulin secretion	Mus musculus	-

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Release 2023.1 (January 2023)