Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Triton X-100 | maximal activity at 0.025% | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diisopropyl fluorophosphate | IC50: 8 mM | Sus scrofa | |
dithiothreitol | 1 mM, complete inhibition | Sus scrofa | |
DNA containing thymine glycol | 0.05 mM, 50% inhibition | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Sus scrofa | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Sus scrofa | - |
2-acylglycerophosphocholine + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Triton X-100, Blue-Toyopearl, Red-Toyopearl, DEAE-Toyopearl, Green-agarose, Brown-agarose, Polylysine-agarose, Palmitoyl-CoA-agarose, Blue-5PW | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
platelet | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.42 | - |
- |
Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acyl-lysophosphtidic acid + H2O | 7% of activity with phosphatidic acid | Sus scrofa | glycerol-3-phosphate + a carboxylate | - |
? | |
phosphatidic acid + H2O | - |
Sus scrofa | lysophosphatidic acid + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Sus scrofa | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | 7% of activity with phosphatidic acid, at 0.1% Triton X-100 | Sus scrofa | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylinositol + H2O | 1% of activity with phosphatidic acid, at 0.1% Triton X-100 | Sus scrofa | lysophosphatidylinositol + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PA-PLA1 | - |
Sus scrofa |
phosphatidic acid-specific phospholipase A1 | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Sus scrofa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.2 | 9.5 | approx. 6% of maximal activity at pH 6.2, approx. 23% of maximal activity at pH 9.5 | Sus scrofa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
8 | - |
IC50: 8 mM | Sus scrofa | diisopropyl fluorophosphate |