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Literature summary for 3.1.1.32 extracted from

  • Miyazawa, D.; Ikemoto, A.; Fujii, Y.; Okuyama, H.
    Partial purification and characterization of phosphatidic acid-specific phospholipase A1 in porcine platelet membranes (2003), Biochim. Biophys. Acta, 1631, 17-25.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 maximal activity at 0.025% Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate IC50: 8 mM Sus scrofa
dithiothreitol 1 mM, complete inhibition Sus scrofa
DNA containing thymine glycol 0.05 mM, 50% inhibition Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Sus scrofa 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Sus scrofa
-
2-acylglycerophosphocholine + a carboxylate
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Triton X-100, Blue-Toyopearl, Red-Toyopearl, DEAE-Toyopearl, Green-agarose, Brown-agarose, Polylysine-agarose, Palmitoyl-CoA-agarose, Blue-5PW Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.42
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acyl-lysophosphtidic acid + H2O 7% of activity with phosphatidic acid Sus scrofa glycerol-3-phosphate + a carboxylate
-
?
phosphatidic acid + H2O
-
Sus scrofa lysophosphatidic acid + a carboxylate
-
?
phosphatidylcholine + H2O
-
Sus scrofa 2-acylglycerophosphocholine + a carboxylate
-
?
phosphatidylcholine + H2O 7% of activity with phosphatidic acid, at 0.1% Triton X-100 Sus scrofa 2-acylglycerophosphocholine + a carboxylate
-
?
phosphatidylinositol + H2O 1% of activity with phosphatidic acid, at 0.1% Triton X-100 Sus scrofa lysophosphatidylinositol + a carboxylate
-
?

Synonyms

Synonyms Comment Organism
PA-PLA1
-
Sus scrofa
phosphatidic acid-specific phospholipase A1
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
6.2 9.5 approx. 6% of maximal activity at pH 6.2, approx. 23% of maximal activity at pH 9.5 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
8
-
IC50: 8 mM Sus scrofa diisopropyl fluorophosphate