Literature summary for 3.1.1.31 extracted from

Calligari, P.A.; Salgado, G.F.; Pelupessy, P.; Lopes, P.; Ouazzani, J.; Bodenhausen, G.; Abergel, D.
Insights into internal dynamics of 6-phosphogluconolactonase from Trypanosoma brucei studied by nuclear magnetic resonance and molecular dynamics (2012), Proteins, 80, 1196-1210.

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Application

Application	Comment	Organism
drug development	the enzyme is a target for anti-parasite drug development	Trypanosoma brucei

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
glycosome	-	Trypanosoma brucei	20015	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-phospho-D-glucono-1,5-lactone + H2O	Trypanosoma brucei	-	6-phospho-D-gluconate	-	?

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-phospho-D-glucono-1,5-lactone + H2O	-	Trypanosoma brucei	6-phospho-D-gluconate	-	?

Synonyms

Synonyms	Comment	Organism
6PGL	-	Trypanosoma brucei

General Information

General Information	Comment	Organism
metabolism	the enzyme is one of the six enzymes of the pentose phosphate pathway of Trypanosoma brucei and hydrolyzes D-6-phosphogluconolactone to 6-phosphogluconic acid	Trypanosoma brucei
additional information	analysis of effects of ligand binding on the internal dynamics of the enzyme by molecular dynamics simulations and nuclear magnetic resonance, alterations of conformational exchange, overview. Residues R77 and R200, located near the active site, interact directly with the phosphate group of 6-phospho-D-gluconate. Residue H165 is actively involved in catalysis	Trypanosoma brucei
physiological function	the enzyme plays a key role during infection, by providing the important reductive agent NADPH, and forms ribose 5-phosphate, a major nucleic acid precursor, as well as several metabolic intermediates, such as fructose 6-phosphate and glyceraldehyde 3-phosphate	Trypanosoma brucei

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Release 2023.1 (January 2023)