Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trypanosoma brucei |
expression in Escherichia coli | Homo sapiens |
expression of lactonase domain Pf6PGL in Escherichia coli, low recovery of soluble Pf6PGL | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-glucono-1,5-lactone + H2O | Trypanosoma brucei | - |
6-phospho-D-gluconate | - |
? | |
6-phospho-D-glucono-1,5-lactone + H2O | Homo sapiens | - |
6-phospho-D-gluconate | - |
? | |
6-phospho-D-glucono-1,5-lactone + H2O | Plasmodium falciparum | - |
6-phospho-D-gluconate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95336 | - |
- |
Plasmodium falciparum | Q27741 | bifunctional enzyme having both glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase activity | - |
Trypanosoma brucei | Q9GRG6 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant 6PGL | Trypanosoma brucei |
recombinant 6PGL | Homo sapiens |
recombinant 6PGL | Plasmodium falciparum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
60 | - |
recombinant 6PGL | Plasmodium falciparum |
180 | - |
recombinant 6PGL | Trypanosoma brucei |
3330 | - |
recombinant 6PGL | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-glucono-1,5-lactone + H2O | - |
Trypanosoma brucei | 6-phospho-D-gluconate | - |
? | |
6-phospho-D-glucono-1,5-lactone + H2O | - |
Homo sapiens | 6-phospho-D-gluconate | - |
? | |
6-phospho-D-glucono-1,5-lactone + H2O | - |
Plasmodium falciparum | 6-phospho-D-gluconate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconolactonase | - |
Trypanosoma brucei |
6-phosphogluconolactonase | - |
Homo sapiens |
6-phosphogluconolactonase | - |
Plasmodium falciparum |
6PGL | - |
Trypanosoma brucei |
6PGL | - |
Homo sapiens |
6PGL-G6PDH | - |
Plasmodium falciparum |
Pf6PGL | - |
Plasmodium falciparum |