Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.3 extracted from

  • Radovic, B.; Aflaki, E.; Kratky, D.
    Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis (2012), Biol. Chem., 393, 1005-1011.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
CGI-58 lipid droplet-binding protein Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Mus musculus
-
diacylglycerol + a carboxylate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
-
Mus musculus
-
macrophage
-
Mus musculus
-
white adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme lacks the ability to hydrolyze monoacylglycerol, CEs, or retinyl esters Mus musculus ?
-
?
triacylglycerol + H2O
-
Mus musculus diacylglycerol + a carboxylate
-
?

Synonyms

Synonyms Comment Organism
adipose triglyceride lipase
-
Mus musculus
ATGL
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice show an increased utilization of carbohydrates as an energy source, leading to improved glucose tolerance and insulin sensitivity. Enzyme-deficient male mice are fertile, whereas females lack the ability to suckle their offspring due to impaired milk production. Enzyme-deficient mice exhibit defective thermogenesis in brown adipose tissue. Enzyme-deficient macrophages accumulate triacylglycerol-rich lipid droplets resulting in altered cell morphology that resemble macrophage foam cells. ATGL deficiency attenuates the mRNA expression of the proinflammatory chemokine (C-X-C motif) ligand 1 (Gro1) and the release of interleukin-6 from macrophages. Enzyme deficiency limits adipose tissue macrophage accumulation during fasting Mus musculus