Activating Compound | Comment | Organism | Structure |
---|---|---|---|
HDL | HDL is able to displace cell surface-bound hepatic lipase and stimulate vascular triglyceride hydrolysis, much like heparin. HDL fractions from hyperlipidemic patients are unable to displace HL from the cell surface | Homo sapiens | |
heparin | heparin promotes the displacement of hepatic lipase and lipoprotein lipase from the liver and vascular endothelium and stimulates lipolytic activity and plasma triglyceride clearance | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | changes in HDL cholesteryl ester and fatty acid content have no effect on hepatic lipase displacement, increases in HDL phospholipid and TG content significantly inhibit hepatic lipase displacement | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | bound | Homo sapiens | 9986 | - |
additional information | HDL is able to displace cell surface-bound hepatic lipase and stimulate vascular triglyceride hydrolysis, much like heparin | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
healthy persons and hypercholesterolemic patients | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
vascular endothelium | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
hepatic lipase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | HDL particles in plasma are central to regulation of hepatic lipase displacement and the hydrolytic activity of hepatic lipase, overview | Homo sapiens |