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Literature summary for 3.1.1.3 extracted from

  • Rouhani, N.; Young, E.; Chatterjee, C.; Sparks, D.L.
    HDL composition regulates displacement of cell surface-bound hepatic lipase (2008), Lipids, 43, 793-804.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
HDL HDL is able to displace cell surface-bound hepatic lipase and stimulate vascular triglyceride hydrolysis, much like heparin. HDL fractions from hyperlipidemic patients are unable to displace HL from the cell surface Homo sapiens
heparin heparin promotes the displacement of hepatic lipase and lipoprotein lipase from the liver and vascular endothelium and stimulates lipolytic activity and plasma triglyceride clearance Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information changes in HDL cholesteryl ester and fatty acid content have no effect on hepatic lipase displacement, increases in HDL phospholipid and TG content significantly inhibit hepatic lipase displacement Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface bound Homo sapiens 9986
-
additional information HDL is able to displace cell surface-bound hepatic lipase and stimulate vascular triglyceride hydrolysis, much like heparin Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
healthy persons and hypercholesterolemic patients
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-
vascular endothelium
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
hepatic lipase
-
Homo sapiens

General Information

General Information Comment Organism
additional information HDL particles in plasma are central to regulation of hepatic lipase displacement and the hydrolytic activity of hepatic lipase, overview Homo sapiens