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Literature summary for 3.1.1.3 extracted from

  • Clarenbach, J.J.; Vega, G.L.; Adams-Huet, B.; Considine, R.V.; Ricks, M.; Sumner, A.E.
    Variability in postheparin hepatic lipase activity is associated with plasma adiponectin levels in African Americans (2007), J. Investig. Med., 55, 187-194.
    View publication on PubMed
Search for more literature for 3.1.1.3

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.038
-
 1,2-didecanoyl-1-thioglycerol 37°C, pH 7.4 Bos taurus
0.055
-
 1-stearoyl-2-arachidonoyl-sn-glycerol 37°C, pH 7.4 Bos taurus
0.063
-
 1-stearoyl-2-arachidonoyl-sn-glycerol 37°C, pH 7.4 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 x * 27000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus diacylglycerol lipase may regulate protein kinase C activity and 2-arachidonoyl-sn-glycerol levels by rapidly altering the intracellular concentration of diacylglycerols ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus Q2KI18
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation by cAMP-dependent protein kinase results in a three-fold increase in catalytic thrpoughput Bos taurus

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-didecanoyl-1-thioglycerol + H2O
-
 Bos taurus ?
-
 ?
1-stearoyl-2-arachidonoyl-sn-glycerol + H2O
-
 Bos taurus ?
-
 ?
additional information diacylglycerol lipase may regulate protein kinase C activity and 2-arachidonoyl-sn-glycerol levels by rapidly altering the intracellular concentration of diacylglycerols Bos taurus ?
-
 ?
additional information 1,2-diacyl-sn-glycerols are the preferred substrates over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1-position of 1,2-diacyl-sn-glycerols. 1-O-alkyl-2-acyl-sn-glycerols are not a substrate for the enzyme Bos taurus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 27000, SDS-PAGE Bos taurus

Synonyms

Synonyms Comment Organism
diacylglycerol lipase
-
 Bos taurus