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Literature summary for 3.1.1.29 extracted from

  • Das, G.; Varshney, U.
    Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis (2006), Microbiology, 152, 2191-2195.
    View publication on PubMed
Search for more literature for 3.1.1.29

Application

Application Comment Organism
drug development Pth is a potential drug target to control eubacterial infections Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli genetic interactions and the mechanism of peptidyl-tRNA drop-off of translating ribosomes leading to accumutaion of peptidyl-tRNA, overview ?
-
 ?
peptidyl-tRNAL + H2O Escherichia coli Pth is a key protein at the crossroads to the function of several translational factors, accumulation of peptidyl-tRNA in the cells leads to depletion of aminoacyl-tRNA pools and halts protein biosynthesis, it is vital for cells to maintain Pth activity to deal with the pollution of peptidyl-tRNAs generated during the initiation, elongation and termination steps of protein biosynthesis, overview peptide + tRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 mutant strain with temperature-sensitive Pth, gene pth
-

Reaction

Reaction Comment Organism Reaction ID
N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA reaction mechanism, active-site residues N10, H20 and D93 are crucial for catalysis Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information genetic interactions and the mechanism of peptidyl-tRNA drop-off of translating ribosomes leading to accumutaion of peptidyl-tRNA, overview Escherichia coli ?
-
 ?
peptidyl-tRNAL + H2O Pth is a key protein at the crossroads to the function of several translational factors, accumulation of peptidyl-tRNA in the cells leads to depletion of aminoacyl-tRNA pools and halts protein biosynthesis, it is vital for cells to maintain Pth activity to deal with the pollution of peptidyl-tRNAs generated during the initiation, elongation and termination steps of protein biosynthesis, overview Escherichia coli peptide + tRNA
-
 ?
peptidyl-tRNAL + H2O Pth prefers substrates with two or more peptide bonds compared to those with a single peptide bond Escherichia coli peptide + tRNA
-
 ?

Synonyms

Synonyms Comment Organism
peptidyl-tRNA hydrolase
-
 Escherichia coli
PTH
-
 Escherichia coli