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Literature summary for 3.1.1.23 extracted from
- Molecular and biochemical characterizations of the monoacylglycerol lipase gene family of Arabidopsis thaliana (2016), Plant J., 85, 758-771 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression of C-terminally eYFP-tagged enzyme tobacco epidermal cells or protoplast cells | Arabidopsis thaliana |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL8 | Arabidopsis thaliana |  |
| 0.16 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL15 | Arabidopsis thaliana | |
| 0.16 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL6 | Arabidopsis thaliana | |
| 0.17 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL1 | Arabidopsis thaliana | |
| 0.17 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL10 | Arabidopsis thaliana | |
| 0.17 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL9 | Arabidopsis thaliana | |
| 0.2 | 0.25 | monoacylglycerol | pH 8.0, 30°C, AtMAGL2 | Arabidopsis thaliana | |
| 0.2 | 0.25 | monoacylglycerol | pH 8.0, 30°C, AtMAGL4 | Arabidopsis thaliana | |
| 0.2 | 0.25 | monoacylglycerol | pH 8.0, 30°C, AtMAGL7 | Arabidopsis thaliana | |
| 0.22 | - |
lysophosphatidylethanolamine | pH 8.0, 30°C, AtMAGL4 | Arabidopsis thaliana | |
| 0.24 | - |
lysophosphatidylethanolamine | pH 8.0, 30°C, AtMAGL4 | Arabidopsis thaliana | |
| 0.25 | - |
lysophosphatidylcholine | pH 8.0, 30°C, AtMAGL4 | Arabidopsis thaliana | |
| 0.28 | - |
lysophosphatidylethanolamine | pH 8.0, 30°C, AtMAGL1 | Arabidopsis thaliana | |
| 0.3 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL14 | Arabidopsis thaliana | |
| 0.3 | - |
monoacylglycerol | pH 8.0, 30°C, AtMAGL16 | Arabidopsis thaliana | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Arabidopsis thaliana | 5829 | - |
| endoplasmic reticulum | - |
Arabidopsis thaliana | 5783 | - |
| Golgi apparatus | - |
Arabidopsis thaliana | 5794 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Arabidopsis thaliana | O23179 | - |
- |
| Arabidopsis thaliana | O23180 | - |
- |
| Arabidopsis thaliana | O23181 | - |
- |
| Arabidopsis thaliana | O48723 | - |
- |
| Arabidopsis thaliana | O49284 | - |
- |
| Arabidopsis thaliana | O80959 | - |
- |
| Arabidopsis thaliana | Q8H133 | - |
- |
| Arabidopsis thaliana | Q93ZQ3 | - |
- |
| Arabidopsis thaliana | Q9FIY1 | - |
- |
| Arabidopsis thaliana | Q9SV43 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.07 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL14 | Arabidopsis thaliana |
| 0.08 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL4 | Arabidopsis thaliana |
| 0.09 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL14 | Arabidopsis thaliana |
| 0.14 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL10 | Arabidopsis thaliana |
| 0.16 | - |
lysophosphatidylethanolamine, pH 8.0, 38°C, AtMAGL1 | Arabidopsis thaliana |
| 0.17 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL14 | Arabidopsis thaliana |
| 0.2 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL9 | Arabidopsis thaliana |
| 0.33 | - |
lysophosphatidylethanolamine, pH 8.0, 38°C, AtMAGL2 | Arabidopsis thaliana |
| 0.38 | - |
lysophosphatidylcholine, pH 8.0, 38°C, AtMAGL4 | Arabidopsis thaliana |
| 0.41 | - |
lysophosphatidylethanolamine, pH 8.0, 38°C, AtMAGL4 | Arabidopsis thaliana |
| 0.52 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL1 | Arabidopsis thaliana |
| 0.63 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL2 | Arabidopsis thaliana |
| 1.77 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL7 | Arabidopsis thaliana |
| 12.11 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL8 | Arabidopsis thaliana |
| 23.93 | - |
monoacylglycerol substrate, pH 8.0, 38°C, AtMAGL6 | Arabidopsis thaliana |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lysophosphatidylcholine + H2O | - |
Arabidopsis thaliana | fatty acid + glycerophosphocholine | - |
? | |
| lysophosphatidylethanolamine + H2O | - |
Arabidopsis thaliana | fatty acid + glycerophosphoethanolamine | - |
? | |
| monoacylglycerol + H2O | - |
Arabidopsis thaliana | fatty acid + glycerol | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL1 is active with monoacylglycerol and lysophosphatidylethanolamine substrates, but not with diacylglycerol, triacylglycerol, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL10 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL11 is inactive with monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, and lysophosphatidylethanolamine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL14 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozymes regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL15 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozymes regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL16 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozymes regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL2 is active with monoacylglycerol and lysophosphatidylethanolamine substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylcholine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL3 is inactive with monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, and lysophosphatidylethanolamine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL4 is active with monoacylglycerol, lysophosphatidylcholine, and lysophosphatidylethanolamine substrates, but not with diacylglycerol, and triacylglycerol substrates as well as with monogalactosyldiacylglycerol and digalactosyldiacylglycerol substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL5 is inactive with monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL6 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL7 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL8 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
| additional information | usage of various lipid substrates containing 18:2 fatty acids at the sn-1 (monoacylglycerol, diacylglycerol, triacylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, monogalactosyldiacylglycerol, and digalactosyldiacylglycerol), sn-2 (triacylglycerol and digalactosyldiacylglycerol), and sn-3 (diacylglycerol, triacylglycerol) positions. Isozyme AtMAGL9 is active with monoacylglycerol substrates, but not with diacylglycerol, triacylglycerol, lysophosphatidylethanolamine, and lysophosphatidylcholine substrates. Isozyme regiospecificities and substrate specificities, specificities for monoacylglycerols with various fatty acids at sn-1 position, overview | Arabidopsis thaliana | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AtMAGL | - |
Arabidopsis thaliana |
| AtMAGL1 | - |
Arabidopsis thaliana |
| AtMAGL10 | - |
Arabidopsis thaliana |
| AtMAGL11 | - |
Arabidopsis thaliana |
| AtMAGL14 | - |
Arabidopsis thaliana |
| AtMAGL15 | - |
Arabidopsis thaliana |
| AtMAGL16 | - |
Arabidopsis thaliana |
| AtMAGL2 | - |
Arabidopsis thaliana |
| AtMAGL3 | - |
Arabidopsis thaliana |
| AtMAGL4 | - |
Arabidopsis thaliana |
| AtMAGL5 | - |
Arabidopsis thaliana |
| AtMAGL6 | - |
Arabidopsis thaliana |
| AtMAGL7 | - |
Arabidopsis thaliana |
| AtMAGL8 | - |
Arabidopsis thaliana |
| AtMAGL9 | - |
Arabidopsis thaliana |
| MAGL | - |
Arabidopsis thaliana |
| monoacylglycerol lipase | - |
Arabidopsis thaliana |
| patatin-like protein 1 | UniProt | Arabidopsis thaliana |
| patatin-like protein 2 | UniProt | Arabidopsis thaliana |
| patatin-like protein 3 | UniProt | Arabidopsis thaliana |
| patatin-like protein 4 | UniProt | Arabidopsis thaliana |
| patatin-like protein 5 | UniProt | Arabidopsis thaliana |
| patatin-like protein 6 | UniProt | Arabidopsis thaliana |
| patatin-like protein 7 | UniProt | Arabidopsis thaliana |
| patatin-like protein 8 | UniProt | Arabidopsis thaliana |
| patatin-like protein 9 | UniProt | Arabidopsis thaliana |
| PLP1 | - |
Arabidopsis thaliana |
| PLP2 | - |
Arabidopsis thaliana |
| PLP3 | - |
Arabidopsis thaliana |
| PLP4 | - |
Arabidopsis thaliana |
| PLP5 | - |
Arabidopsis thaliana |
| PLP6 | - |
Arabidopsis thaliana |
| PLP7 | - |
Arabidopsis thaliana |
| PLP8 | - |
Arabidopsis thaliana |
| PLP9 | - |
Arabidopsis thaliana |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Arabidopsis thaliana |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Arabidopsis thaliana |
| 8 | 9 | - |
Arabidopsis thaliana |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9.5 | activity range, profile overview | Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | monoacylglycerol lipases (MAGLs) catalyze the last step of triacylglycerol breakdown, which is the hydrolysis of monoacylglycerol (MAG) to fatty acid and glycerol | Arabidopsis thaliana |
| additional information | computational three-dimensional structure modeling | Arabidopsis thaliana |
| additional information | computational three-dimensional structure modeling. Comparison of three dimensional protein models between Arabidopsis monoacylglycerol lipase (AtMAGL8) and the human protein | Arabidopsis thaliana |
| physiological function | monoacylglycerol lipases (MAGLs) catalyze the last step of triacylglycerol breakdown, which is the hydrolysis of monoacylglycerol (MAG) to fatty acid and glycerol | Arabidopsis thaliana |
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