Application | Comment | Organism |
---|---|---|
diagnostics | enzyme MGLL in tumor-associated macrophages predicts the survival of colorectal cancer patients | Homo sapiens |
medicine | expression of macrophage MGLL is decreased in cancer tissues and positively correlated with the survival of cancer patients. Monoacylglycerol lipase is a switch for CB2/TLR4-dependent macrophage activation and a potential target for cancer therapy. Modulation of MGLL-CB2 axis in macrophages might be a promising strategy for cancer treatment | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the transgene of human MGLL in macrophages largely prolonges the survival of MC-38 tumor-bearing mice | Homo sapiens |
additional information | the transgene of human MGLL in macrophages largely prolonges the survival of MC-38 tumor-bearing mice, employment of Rag1 knockout mouse model with lymphocyte deficiency, the antitumor effect of macrophage MGLL is largely attenuated in Rag1 knockout mouse, incidence of lung metastasis in MC-38 tumors is 100%, regardless of wild-type or TgMGLL KO mice, and cytokine expression does not differ between the wild-type and TgMGLL KO macrophages from the spleens of MC-38 tumor-bearing mice. Bone marrow-derived macrophages with the MGLL transgene express much higher levels of IL-1beta and TNFalpha in response to IFNgamma and LPS stimulation and notably lower levels of IL-10, Arg-1, and TGFbeta in response to IL-4 treatment | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q99685 | - |
- |
Mus musculus | O35678 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | expression of macrophage MGLL is decreased in cancer tissues | Mus musculus | - |
colonic cancer cell | expression of macrophage MGLL is decreased in cancer tissues and positively correlated with the survival of cancer patients | Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
macrophage | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
MGLL | - |
Homo sapiens |
MGLL | - |
Mus musculus |
monoacylglycerol lipase | - |
Homo sapiens |
monoacylglycerol lipase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency of monoacylglycerol lipase (MGLL) results in lipid overload in tumor-associated macrophages. MGLL deficiency promotes CB2/TLR4-dependent macrophage activation, which further suppresses the function of tumor-associated CD8+ T cells, and contributes to lipid accumulation. Treatment with CB2 antagonists delays tumor progression in inoculated and genetic cancer models | Homo sapiens |
malfunction | deficiency of monoacylglycerol lipase (MGLL) results in lipid overload in tumor-associated macrophages. MGLL deficiency promotes CB2/TLR4-dependent macrophage activation, which further suppresses the function of tumor-associated CD8+ T cells, and contributes to lipid accumulation. Treatment with CB2 antagonists delays tumor progression in inoculated and genetic cancer models | Mus musculus |
physiological function | monoacylglycerol lipase (MGLL) regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Analysis of mechanism underlying MGLL-CB2-regulated macrophage activation using in vitro and mouse models with pharmacological or genetic manipulation. MGLL/CB2 regulates tumor progression in mice, macrophage MGLL inhibits tumor progression via CD8+ T cells, mechanism, overview. MGLL regulates macrophage activity via CB2/TLR4 interaction, CB2 antagonizes TLR-4 signaling in macrophages | Mus musculus |
physiological function | monoacylglycerol lipase (MGLL) regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Analysis of mechanism underlying MGLL-CB2-regulated macrophage activation using in vitro and mouse models with pharmacological or genetic manipulation. Modulation of MGLL-CB2 axis in macrophages might be a promising strategy for cancer treatment. Macrophage MGLL inhibits tumor progression via CD8+ T cells, mechanism, overview. MGLL regulates macrophage activity via CB2/TLR4 interaction | Homo sapiens |