Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no effect by DTT at 0.1 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone | - |
Homo sapiens | |
12-deacetylsplendidin C | poor inhibition | Homo sapiens | |
2-dehydroxysalvileucanthsin A | poor inhibition | Homo sapiens | |
eriodictyol | - |
Homo sapiens | |
jewenol A | reversible inhibitor, catalytic site binding structure, overview | Homo sapiens | |
additional information | diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL), NMR structure analysis, molecular docking into the catalytic site of the enzyme, overview. No effect by DTT at 0.1 mM and by galloflavin | Homo sapiens | |
oleanolic acid | - |
Homo sapiens | |
pedalitin | - |
Homo sapiens | |
Protocatechualdehyde | - |
Homo sapiens | |
pseudorosmaricin | poor inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q99685 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAGL | - |
Homo sapiens |
monoacylglycerol lipase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0117 | - |
pH 7.2, temperature not specified in the publication | Homo sapiens | (4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone | |
0.0468 | - |
pH 7.2, temperature not specified in the publication | Homo sapiens | jewenol A | |
0.2 | - |
above, pH 7.2, temperature not specified in the publication | Homo sapiens | 12-deacetylsplendidin C | |
0.2 | - |
above, pH 7.2, temperature not specified in the publication | Homo sapiens | 2-dehydroxysalvileucanthsin A | |
0.2 | - |
above, pH 7.2, temperature not specified in the publication | Homo sapiens | pseudorosmaricin |