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Literature summary for 3.1.1.23 extracted from

  • Vila, A.; Rosengarth, A.; Piomelli, D.; Cravatt, B.; Marnett, L.J.
    Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase (2007), Biochemistry, 46, 9578-9585.
    View publication on PubMed
Search for more literature for 3.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
URB-602 a specific MGL inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 2-arachidonoylglycerol pH 8.0, 37°C Rattus norvegicus
0.133
-
 prostaglandin D2-G pH 8.0, 37°C Rattus norvegicus
0.15
-
 prostaglandin E2-G pH 8.0, 37°C Rattus norvegicus
0.311
-
 prostaglandin F3alpha-G pH 8.0, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in prostaglandin metabolism in brain particulate fractions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
 Rattus norvegicus arachidonic acid + glycerol
-
 ?
additional information substrate specificity, overview Rattus norvegicus ?
-
 ?
additional information the enzyme is involved in prostaglandin metabolism in brain particulate fractions Rattus norvegicus ?
-
 ?
prostaglandin D2-G + H2O
-
 Rattus norvegicus ?
-
 ?
prostaglandin E2-G + H2O
-
 Rattus norvegicus ?
-
 ?
prostaglandin F3alpha-G + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
MGL
-
 Rattus norvegicus
monoacylglycerol lipase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.07
-
 prostaglandin D2-G pH 8.0, 37°C Rattus norvegicus
0.14
-
 prostaglandin F3alpha-G pH 8.0, 37°C Rattus norvegicus
0.16
-
 prostaglandin E2-G pH 8.0, 37°C Rattus norvegicus
0.35
-
 2-arachidonoylglycerol pH 8.0, 37°C Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Rattus norvegicus