Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.23 extracted from

  • Vandevoorde, S.; Fowler, C.J.
    Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate (2005), Br. J. Pharmacol., 145, 885-893.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by URB597, bovine serum albumin decreases the inhibitory effect of arachidonoyl-based compounds, e.g. VDM11 Rattus norvegicus
N-(4-hydroxy-2-methylphenyl)arachidonylamide i.e. VDM11, an anandamide uptake inhibitor, substrate of fatty acid amide hydrolase, EC 3.5.1.4, IC50 is 0.021 mM Rattus norvegicus
N-(4-hydroxyphenyl)arachidonylamide i.e. AM404, an anandamide uptake inhibitor, substrate of fatty acid amide hydrolase, EC 3.5.1.4, IC50 is 0.020 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
membrane
-
 Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-arachidonoylglycerol + H2O Rattus norvegicus
-
 arachidonic acid + glycerol
-
 ?
2-arachidonoylglycerol + H2O Rattus norvegicus Sprague-Dawley
-
 arachidonic acid + glycerol
-
 ?
2-oleoylglycerol + H2O Rattus norvegicus
-
 oleic acid + glycerol
-
 ?
2-oleoylglycerol + H2O Rattus norvegicus Sprague-Dawley
-
 oleic acid + glycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
 Rattus norvegicus arachidonic acid + glycerol
-
 ?
2-arachidonoylglycerol + H2O
-
 Rattus norvegicus Sprague-Dawley arachidonic acid + glycerol
-
 ?
2-oleoylglycerol + H2O
-
 Rattus norvegicus oleic acid + glycerol
-
 ?
2-oleoylglycerol + H2O
-
 Rattus norvegicus Sprague-Dawley oleic acid + glycerol
-
 ?

Synonyms

Synonyms Comment Organism
MAGL
-
 Rattus norvegicus
monoacylglycerol lipase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02
-
 i.e. AM404, an anandamide uptake inhibitor, substrate of fatty acid amide hydrolase, EC 3.5.1.4, IC50 is 0.020 mM Rattus norvegicus N-(4-hydroxyphenyl)arachidonylamide
0.021
-
 i.e. VDM11, an anandamide uptake inhibitor, substrate of fatty acid amide hydrolase, EC 3.5.1.4, IC50 is 0.021 mM Rattus norvegicus N-(4-hydroxy-2-methylphenyl)arachidonylamide