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Literature summary for 3.1.1.23 extracted from

  • Dinh, T.P.; Carpenter, D.; Leslie, F.M.; Freund, T.F.; Katona, I.; Sensi, S.L.; Kathuria, S.; Piomelli, D.
    Brain monoglyceride lipase participating in endocannabinoid inactivation (2002), Proc. Natl. Acad. Sci. USA, 99, 10819-10824.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.23

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
arachidonoyl trifluoromethylketone 50% inhibition at 0.0025 mM Rattus norvegicus
hexadecylsufonyl fluoride 50% inhibition at 0.0062 mM Rattus norvegicus
methyl arachidonyl fluorophosphonate 50% inhibition at 0.0008 mM Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33370
-
 calculated from amino acid sequence Rattus norvegicus
35000
-
 two closely related isoforms of 35000 Da and 37000 Da, SDS-PAGE Rattus norvegicus
37000
-
 two closely related isoforms of 35000 Da and 37000 Da, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q8R431
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-
cerebral cortex
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
thalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
 Rattus norvegicus arachidonic acid + glycerol
-
 ?
2-monooleoylglycerol + H2O
-
 Rattus norvegicus oleic acid + glycerol
-
 r
additional information enzyme does not hydrolyze palmitoylethanolamine, enzyme preferentially hydrolyzes 2-monoglycerides Rattus norvegicus ?
-
 ?