Application | Comment | Organism |
---|---|---|
medicine | PON1 moderately indicates cancer presence and regional metastasis, PON1 activity decreases in gastroesophageal cancers and corresponds to inflammation severity and cancer-related anemia, PON1's arylesterase activity reflects anemia severity, being correlated with hemoglobin, hematocrit, and iron | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Q192R | paraoxon is less efficiently hydrolysed compared to the wild type enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
esophageal squamous cell carcinoma cell | - |
Homo sapiens | - |
gastroesophageal adenocarcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phenyl acetate + H2O | arylesterase activity of PON1 | Homo sapiens | phenol + acetate | - |
? |