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Literature summary for 3.1.1.2 extracted from
- Paraoxonase 1 (PON1) status in gastroesophageal malignancies and associated paraneoplastic syndromes - connection with inflammation (2008), Clin. Biochem., 41, 804-811.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PON1 moderately indicates cancer presence and regional metastasis, PON1 activity decreases in gastroesophageal cancers and corresponds to inflammation severity and cancer-related anemia, PON1's arylesterase activity reflects anemia severity, being correlated with hemoglobin, hematocrit, and iron | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Q192R | paraoxon is less efficiently hydrolysed compared to the wild type enzyme | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27169 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| esophageal squamous cell carcinoma cell | - |
Homo sapiens | - |
| gastroesophageal adenocarcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phenyl acetate + H2O | arylesterase activity of PON1 | Homo sapiens | phenol + acetate | - |
? |  |
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Release 2023.1 (January 2023)
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