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Literature summary for 3.1.1.2 extracted from
- Effect of 3,4-dihydroxyphenylalanine on Cu2+-induced inactivation of HDL-associated paraoxonase1 and oxidation of HDL; inactivation of paraoxonase1 activity independent of HDL lipid oxidation (2004), Free Radic. Res., 38, 969-976.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| butylated hydroxytoluene | - |
Homo sapiens |  |
| Cu2+ | oxidizes HDL and inactivates HDL-associated paraoxonase1, relationship, overview, the inactivation is enhanced catecholamines, such as 3,4-dihydroxyphenylalanine, dopamine, or norepinephrine, but not by uric acid or homocysteine, low enhancement of Cu2+-mediated enzyme inactivation by catecholamines caffeic acid and pyrocatechol, and by ascorbate, effects on activity of purified enzyme and HDL-complexed enzyme, overview, the inactivation in prevented by several compounds, e.g. by catalase, ethanol, oleic acid, substrate paraoxon, phenylacetate, and slightly by quercetin, mannitol, and DMSO in presence of 1 mM Ca2+ | Homo sapiens | |
| EDTA | - |
Homo sapiens | |
| additional information | the enzyme is sensitive to oxidative stress | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | from plasma | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | added to assay | Homo sapiens | |
| NaCl | added to assay | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is one of the HDL-associated antioxidant proteins, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from plasma of fasted humans by sequential chromatographic steps | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is one of the HDL-associated antioxidant proteins, overview | Homo sapiens | ? | - |
? | |
| phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDL-PON1 | - |
Homo sapiens |
| paraoxonase1 | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 38 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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