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Literature summary for 3.1.1.2 extracted from

  • Kuo, C.L.; La Du, B.N.
    Comparison of purified human and rabbit serum paraoxonases (1995), Drug Metab. Dispos., 23, 935-944.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cardiolipin stimulates Oryctolagus cuniculus
dilauroyl phosphatidylcholine stimulates Homo sapiens
dimyristoyl phosphatidylcholine stimulates Homo sapiens
dimyristoyl phosphatidylcholine stimulates Oryctolagus cuniculus
dioleoyl phosphatidylcholine stimulates Homo sapiens
dioleoyl phosphatidylcholine stimulates Oryctolagus cuniculus
lecithin stimulates Homo sapiens
lecithin stimulates Oryctolagus cuniculus
lysolecithin stimulates Homo sapiens
lysolecithin stimulates Oryctolagus cuniculus
phosphatidylethanolamine stimulates Homo sapiens
phosphatidylethanolamine stimulates Oryctolagus cuniculus
phosphatidylglycerol stimulates Oryctolagus cuniculus
phosphatidylsenine stimulates Oryctolagus cuniculus
sphingomyelin stimulates Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Homo sapiens
EDTA
-
Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites Homo sapiens
Ca2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites Oryctolagus cuniculus
Cd2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Homo sapiens
Cd2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Oryctolagus cuniculus
Zn2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Homo sapiens
Zn2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39800
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE Oryctolagus cuniculus
42300
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein at least 2 N-linked sugar chains, contains sialic acid residues Homo sapiens
glycoprotein at least 2 N-linked sugar chains, contains sialic acid residues Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
Oryctolagus cuniculus
-
blood serum contains A-type paraoxonase and B-type paraoxonase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-naphthyl acetate + H2O 0.1% of the activity with phenyl acetate Oryctolagus cuniculus 1-naphthol + acetate
-
?
1-naphthyl acetate + H2O 0.1% of the activity with phenyl acetate, A-type enzyme. 0.25% of the activity with phenyl acetate, B-type enzyme Homo sapiens 1-naphthol + acetate
-
?
2-naphthyl acetate + H2O 13.5% of the activity with phenyl acetate Oryctolagus cuniculus 2-naphthol + acetate
-
?
2-naphthyl acetate + H2O 5.5% of the activity with phenyl acetate, A-type enzyme. 7% of the activity with phenyl acetate, B-type enzyme Homo sapiens 2-naphthol + acetate
-
?
2-nitrophenyl acetate + H2O 2.1% of the activity with phenyl acetate, A-type enzyme. 2% of the activity with phenyl acetate, B-type enzyme Homo sapiens 2-nitrophenol + acetate
-
?
2-nitrophenyl acetate + H2O 29% of the activity with phenyl acetate Oryctolagus cuniculus 2-nitrophenol + acetate
-
?
4-nitrophenyl acetate + H2O 2.5% of the activity with phenyl acetate, A-type enzyme. 3.5% of the activity with phenyl acetate, B-type enzyme Homo sapiens 4-nitrophenol + acetate
-
?
4-nitrophenyl acetate + H2O 31% of the activity with phenyl acetate Oryctolagus cuniculus 4-nitrophenol + acetate
-
?
phenyl acetate + H2O
-
Homo sapiens phenol + acetate
-
?
phenyl acetate + H2O
-
Oryctolagus cuniculus phenol + acetate
-
?
thiophenyl acetate + H2O 27% of the activity with phenyl acetate, A-type enzyme. 34% of the activity with phenyl acetate, B-type enzyme Homo sapiens ?
-
?
thiophenyl acetate + H2O 30.5% of the activity with phenyl acetate Oryctolagus cuniculus ?
-
?