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Literature summary for 3.1.1.2 extracted from

  • Smolen, A.; Eckerson, H.W.; Gan, K.N.; Hailat, N.; La Du, B.N.
    Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase (1991), Drug Metab. Dispos., 19, 107-112.
    View publication on PubMed
Search for more literature for 3.1.1.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.265
-
 phenyl acetate pH 7.4, 37°C, type B paraoxonase Homo sapiens
0.688
-
 phenyl acetate pH 7.4, 37°C, type A paraoxonase Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
NaCl paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
 x * 43000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-naphthyl acetate + H2O
-
 Homo sapiens 2-naphthol + acetate
-
 ?
2-nitrophenyl acetate + H2O
-
 Homo sapiens 2-nitrophenol + acetate
-
 ?
4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 ?
phenyl acetate + H2O human serum paraoxonase/arylesterase is an esterase with broad substrate specificity. It occurs in two genetically determined allozymic forms, designated types A and B. These allozymes are the products of two allelic genes located at the paraoxonase locus on chromosome 7, which is closely linked to the gene for cystic fibrosis. Paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase. The ratio of paraoxonase activity to arylesterase activity of the B-isozyme is about 8, and that of the A isozyme about 1 Homo sapiens phenol + acetate
-
 ?
thiophenyl acetate + H2O
-
 Homo sapiens thiophenol + acetate
-
 ?

Subunits

Subunits Comment Organism
? x * 43000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
paraoxonase/arylesterase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3373
-
 phenyl acetate pH 7.4, 37°C, type B paraoxonase Homo sapiens
4778
-
 phenyl acetate pH 7.4, 37°C, type A paraoxonase Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens