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Literature summary for 3.1.1.13 extracted from

  • Su, J.; Wang, H.; Ma, C.; Liu, C.; Gao, C.; Nie, R.; Tanver Rahman, M.R.
    Hypocholesterolaemic mechanism of bitter melon aqueous extracts via inhibition of pancreatic cholesterol esterase and reduction of cholesterol micellar solubility (2016), Int. J. Food Sci. Nutr., 67, 20-28 .
    View publication on PubMed
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Application

Application Comment Organism
medicine hypocholesterolaemic mechanism of bitter melon aqueous extracts via inhibition of pancreatic cholesterol esterase and reduction of cholesterol micellar solubility Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information bitter melon aqueous extracts inhibits pancreatic cholesterol esterase in vitro and reduces cholesterol micellar solubility, decrease of alpha-helix contents, increase of beta-sheet and exposure of aromatic amino acid residuals Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P19835
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl butyrate + H2O
-
 Homo sapiens 4-nitrophenol + butyrate
-
 ?

Synonyms

Synonyms Comment Organism
CEase
-
 Homo sapiens
cholesterol esterase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition has a hypocholesterolaemic effect. Inhibition of the enzyme by bitter melon aqueous extract can play a role in decreased intestinal cholesterol absorption, and micelle formation Homo sapiens