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Literature summary for 3.1.1.13 extracted from

  • Muscia, G.C.; Hautmann, S.; Buldain, G.Y.; Asis, S.E.; Guetschow, M.
    Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase (2014), Bioorg. Med. Chem. Lett., 24, 1545-1549.
    View publication on PubMed
Search for more literature for 3.1.1.13

Inhibitors

Inhibitors Comment Organism Structure
2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline competitive mixed-type inhibitor Sus scrofa
2-(3-bromophenyl)-6-chloro-4-phenylquinoline
-
 Sus scrofa
2-(3-bromophenyl)-6-nitro-4-phenylquinoline
-
 Sus scrofa
2-(4-hydroxyphenyl)-6-nitro-4-phenylquinoline
-
 Sus scrofa
2-(4-methylphenyl)-6-nitro-4-phenylquinoline
-
 Sus scrofa
6-chloro-2,4-diphenylquinoline
-
 Sus scrofa
6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline
-
 Sus scrofa
6-chloro-2-(4-hydroxyphenyl)-4-phenylquinoline
-
 Sus scrofa
6-chloro-2-(4-methoxyphenyl)-4-phenylquinoline
-
 Sus scrofa
6-chloro-2-(4-methylphenyl)-4-phenylquinoline
-
 Sus scrofa
6-nitro-2,4-diphenylquinoline
-
 Sus scrofa
additional information not inhibited by 2-(4-methoxyphenyl)-6-nitro-4-phenylquinoline Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesteryl acetate + H2O
-
 Sus scrofa cholesterol + acetate
-
 ?
cholesteryl oleate + H2O
-
 Sus scrofa cholesterol + oleic acid
-
 ?

Synonyms

Synonyms Comment Organism
CEase
-
 Sus scrofa
cholesterol esterase
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00133
-
 at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline
0.00198
-
 at pH 7.0 and 25°C Sus scrofa 2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline
0.00198
-
 at pH 7.0 and 25°C Sus scrofa 2-(3-bromophenyl)-6-nitro-4-phenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2,4-diphenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(4-methylphenyl)-4-phenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(4-hydroxyphenyl)-4-phenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(4-methoxyphenyl)-4-phenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 2-(3-bromophenyl)-6-chloro-4-phenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-nitro-2,4-diphenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 2-(4-methylphenyl)-6-nitro-4-phenylquinoline
0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 2-(4-hydroxyphenyl)-6-nitro-4-phenylquinoline