Any feedback?
Literature summary for 3.1.1.13 extracted from
- Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence (2010), J. Lipid Res., 51, 274-285.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| GFP-tagged enzyme is overexpressed in RAW264.7 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| N270Q | enzyme activity level of the mutant is significantly reduced compared with wild type | Homo sapiens |
| N367Q | enzyme activity level of the mutant is significantly reduced compared with wild type | Homo sapiens |
| N389Q | the mutant shows incomplete glycosylation | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| membrane | NCEH is a single-membrane-spanning type II membrane protein | Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
x * 40000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| macrophage | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleate | - |
? |  |
| additional information | neutral cholesterol ester hydrolase is not a target of protein kinase A | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 40000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NCEH | - |
Homo sapiens |
| neutral cholesterol ester hydrolase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | NCEH hydrolyzes cholesterol ester to deliver cholesterol for efflux out of the macrophage cells | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
