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Literature summary for 3.1.1.13 extracted from

  • Okazaki, H.; Igarashi, M.; Nishi, M.; Sekiya, M.; Tajima, M.; Takase, S.; Takanashi, M.; Ohta, K.; Tamura, Y.; Okazaki, S.; Yahagi, N.; Ohashi, K.; Amemiya-Kudo, M.; Nakagawa, Y.; Nagai, R.; Kadowaki, T.; Osuga, J.; Ishibashi, S.
    Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages (2008), J. Biol. Chem., 283, 33357-33364.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.13

Activating Compound

Activating Compound Comment Organism Structure
NaCl the nCEH activity in the whole cell lysates from NCEH-transfected cells is slightly stimulated by low concentrations of NaCl (6.5% at 0.05 M) Mus musculus
NaCl the nCEH activity in the whole cell lysates from NCEH-transfected cells is slightly stimulated by low concentrations of NaCl (6.5% at 0.05M) Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens
expressed in RAW264.7 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
NaCl 31% inhibition at 1 mM Homo sapiens
NaCl 31% inhibition at 1 mM Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q8BLF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney expressed at high levels in kidney Homo sapiens
-
kidney expressed at high levels in kidney Mus musculus
-
macrophage expressed at high levels in macrophages Homo sapiens
-
macrophage expressed at high levels in peritoneal macrophages Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesteryl oleate + H2O
-
 Homo sapiens cholesterol + oleate
-
 ?
cholesteryl oleate + H2O
-
 Mus musculus cholesterol + oleate
-
 ?

Synonyms

Synonyms Comment Organism
CE hydrolase
-
 Homo sapiens
CE hydrolase
-
 Mus musculus
KIAA1363
-
 Homo sapiens
KIAA1363
-
 Mus musculus
NCEH recombinant enzyme Homo sapiens
NCEH recombinant enzyme Mus musculus
NCEH native enzyme Homo sapiens
NCEH native enzyme Mus musculus
neutral cholesterol ester hydrolase
-
 Homo sapiens
neutral cholesterol ester hydrolase
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
 Homo sapiens
7.2
-
-
 Mus musculus