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Literature summary for 3.1.1.13 extracted from

  • Zhao, B.; Song, J.; Chow, W.N.; St Clair, R.W.; Rudel, L.L.; Ghosh, S.
    Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice (2007), J. Clin. Invest., 117, 2983-2992.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine macrophage-specific expression of enzyme in LDL receptor null mice leads to a significant reduction in the lesion ara and cholesterol content of high-fat, high-cholesterol diet-induced atherosclerotic lesions. Lesions do not show increase in free cholesterol, are less necrotic, and contain significantly higher numbers of viable macrophage foam cells. Higher enzyme-mediated free cholesterol efflux results in enhanced flux of free cholesterol from macrophages to gall bladder bile and feces in vivo Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in LDL receptor null mice Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information macrophage-specific expression of enzyme in LDL receptor null mice leads to a significant reduction in the lesion ara and cholesterol content of high-fat, high-cholesterol diet-induced atherosclerotic lesions. Lesions do not show increase in free cholesterol, are less necrotic, and contain significantly higher numbers of viable macrophage foam cells. Higher enzyme-mediated free cholesterol efflux results in enhanced flux of free cholesterol from macrophages to gall bladder bile and feces in vivo Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-