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Literature summary for 3.1.1.13 extracted from

  • Zhao, B.; Song, J.; St Clair, R.W.; Ghosh, S.
    Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages (2007), Am. J. Physiol. Cell Physiol., 292, C405-C412.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme expression in human macrophages is a potential target for attenuation of foam cell formation and regression of atherosclerotic plaques Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
stable overexpression in human cell line THP1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information stable overexpression in human cell line THP1. Cells show increased enzyme mRNA expression and increased catalytic activity. Efflux of free or unesterified cholesterol by acetylated low density lipoprotein-loaded overexpressing cells is significantly higher than that in wild-type cells. Overexpressing cells accumulate significantly lower amount of esterified cholesterol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-