Application | Comment | Organism |
---|---|---|
medicine | enzyme expression in human macrophages is a potential target for attenuation of foam cell formation and regression of atherosclerotic plaques | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable overexpression in human cell line THP1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | stable overexpression in human cell line THP1. Cells show increased enzyme mRNA expression and increased catalytic activity. Efflux of free or unesterified cholesterol by acetylated low density lipoprotein-loaded overexpressing cells is significantly higher than that in wild-type cells. Overexpressing cells accumulate significantly lower amount of esterified cholesterol | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Homo sapiens | - |