Application | Comment | Organism |
---|---|---|
medicine | selective inhibitors may be useful therapeutics for limiting cholesterol absorption | Mesocricetus auratus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-benzyl-6-chloro-2-pyrone | less selective, potent inhibitor | Mesocricetus auratus | |
6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone | selective, potent, and reversible inhibitor, not toxic in vivo, enzyme inhibition effectively reduces cholesterol uptake in vivo | Mesocricetus auratus | |
additional information | substituted 6-chloro-2-pyrones can be simple reversible inhibitors or irreversible active site inhibitors where an active site nucleophile attacks the 6-postion of the pyrone with release of chloride | Mesocricetus auratus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl oleate + H2O | Mesocricetus auratus | - |
cholesterol + oleate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
male | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
steryl ester + H2O = sterol + fatty acid | a group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts | Mesocricetus auratus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Mesocricetus auratus | - |
pancreas | - |
Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl oleate + H2O | - |
Mesocricetus auratus | cholesterol + oleate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CEase | - |
Mesocricetus auratus |
cholesterol esterase | - |
Mesocricetus auratus |