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Literature summary for 3.1.1.13 extracted from
- Synthesis and hydrolysis of cholesteryl esters by isolated rat-liver lysosomes and cell-free extracts of human lung fibroblasts (1986), Biochim. Biophys. Acta, 879, 221-228.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | esterification doubled | Homo sapiens |  |
| 2-mercaptoethanol | esterification doubled | Rattus sp. | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ammonium chloride | slightly inhibitory | Homo sapiens | |
| ammonium chloride | slightly inhibitory | Rattus sp. | |
| Chloroquine | 90% inhibition at 30 mM | Homo sapiens | |
| Chloroquine | 90% inhibition at 30 mM | Rattus sp. | |
| progesterone | marked inhibition, additive effect if chloroquine is present | Homo sapiens | |
| progesterone | marked inhibition, additive effect if chloroquine is present | Rattus sp. | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Rattus sp. | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | Homo sapiens | involvement in arteriosclerosis | cholesterol + fatty acid | - |
r | |
| cholesteryl esters + H2O | Rattus sp. | involvement in arteriosclerosis | cholesterol + fatty acid | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus sp. | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus sp. | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 80% loss of activity, 2 weeks | Homo sapiens |
| -20°C, 80% loss of activity, 2 weeks | Rattus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | involvement in arteriosclerosis | Homo sapiens | cholesterol + fatty acid | - |
r | |
| cholesteryl esters + H2O | involvement in arteriosclerosis | Rattus sp. | cholesterol + fatty acid | - |
r | |
| cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleic acid | - |
r | |
| cholesteryl oleate + H2O | - |
Rattus sp. | cholesterol + oleic acid | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acid cholesterol esterase | - |
Homo sapiens |
| acid cholesterol esterase | - |
Rattus sp. |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 90 | - |
complete loss of activity after 15 min | Homo sapiens |
| 90 | - |
complete loss of activity after 15 min | Rattus sp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
for synthesis of cholesteryl esters | Homo sapiens |
| 4 | - |
for synthesis of cholesteryl esters | Rattus sp. |
| 4.5 | - |
hydrolysis of cholesteryl esters | Homo sapiens |
| 4.5 | - |
hydrolysis of cholesteryl esters | Rattus sp. |
| 6 | - |
- |
Homo sapiens |
| 6 | - |
- |
Rattus sp. |
| 8 | - |
- |
Homo sapiens |
| 8 | - |
- |
Rattus sp. |
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