Literature summary for 3.1.1.111 extracted from

Guo, M.; Pei, R.; Yang, Q.; Cao, H.; Wang, Y.; Wu, C.; Chen, J.; Zhou, Y.; Hu, X.; Lu, M.; Chen, X.
Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation (2015), J. Virol., 89, 2367-2377 .

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Application

Application	Comment	Organism
medicine	during infection with hepatitis C virus, PLA1A plays an important role in bridging the membrane-associated NS2-E2 complex and the NS5A-associated replication complex via its interaction with E2, NS2, and NS5A	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q53H76	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Huh-7.5.1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	PLA1A is upregulated by hepatitis C virus HCV infection, and PLA1A knockdown significantly reduces J399EM (genotype 2a) HCV propagation at the assembly step but not the entry, RNA replication, and protein translation steps of the life cycle. PLA1A has a role in the interaction of viral proteins NS2-E2 and NS2-NS5A. PLA1A stabilizes the nonstructural proteins NS2/NS5A dotted structure during infection	Homo sapiens

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Release 2023.1 (January 2023)